Category Archives: Issue 4 October 17

Chemo-Boosting Drug Discovered for Leukemia

Acute myeloid leukemia (AML)

 

chemo-boosting-drug-discoveredResearchers have discovered that the most common form of acute leukemia which strikes adults, acute myeloid leukemia (AML), prevents chemotherapy from being delivered properly by causing bone marrow to leak blood. This means that, by using drugs developed to treat blood vessel and heart problems in concert with chemotherapy, AML might be much more treatable. In this study, these drugs reversed bone marrow leaks in tissue from mice and humans, and also boosted chemotherapy effects. Since these drugs are already in clinical trials for other applications, the team hopes that they may be approved for use in the treatment of AML patients soon.

“We found that the cancer was damaging the walls of blood vessels responsible for delivering oxygen, nutrients, and chemotherapy. When we used drugs to stop the leaks in mice, we were able to kill the cancer using conventional chemotherapy,” Diana Passaro, Francis Crick Institute researcher and first author of the paper, said in a press release.

The team studied the ways in which AML affects bone marrow by injecting healthy mice with bone marrow from AML patients to create AML mice. They then used intravital microscopy to compare the bone marrow of AML mice with healthy mice and observed pre-loaded fluorescent dyes leaking from the bone marrow blood vessels into the AML mice. Next, they discovered that the cells lining the blood vessels in AML mice were oxygen-starved, which led to increases in nitric oxide (NO), a muscle relaxant. They realized this was probably causing the leaking, and provided NO blockers to the AML mice which slowed leukemia progress and extended remission.

Bringing cultures together with a mutual love of music.

Four years ago, a small group of friends all with a passion for music formed a band, ProZero,

Over the years ProZero played at some great local venues with some fantastic musicians and gathered a substantial following of Polish fans, before changing their name to CorAdCor.

Just over a year ago CorAdCor invited female vocalist Claire to join them bringing an English flare to the mix.

This year CorAdCor branched out into the English community with the Rec’d all day festival in Widnes and set out to Poland to play the immensely popular Woodstock Festival alongside some talented and well known artist, and hope to return to both in 2018.

After launching a successful Pure Rock Festival in the Polish community last year, CorAdCor plan to launch Pure Rock Festival 2, in association with local production company, Soup Productions to the English music scene in Widnes at The Studio, 5 Lacey St, Widnes WA8 7SQ, on 21st October 2017.

The band hopes this is the beginning of a successful career in both English and Polish communities, bringing the two cultures together with one mutual love….Music.

sebs-band

 

 

 

 

 

 

 

 

 

CorAdCor is a 5 piece band with fusion rock stylings.
Sebastian Fortuna, Claire Williams, Robert Macuda, Grzegorz ‘Gregory’ & Mariusz Kremski

 

Transpharmation happy, animals happy, Datesand happy!

transpharmationIn last month’s Spotlight we were pleased to report a swift and successful outcome to a time-sensitive project we’d taken on Transpharmation. They were very pleased with the device that resulted and said they’d let us have some feedback. True to their word as always, here are their thoughts (rather positive) on the process.

‘Transpharmation is a pre-clinical CRO specialising in translational pharmacology models which help our clients (leading pharmaceutical companies) transition their compounds through to the clinic. Datesand came recommended as a company that would be able to build a bespoke rodent observation chamber for us. This chamber is used to comfortably enclose the animal whilst the behaviours (stimulated responses) are recorded remotely by an observer. We needed this observation chamber tailor made at very short notice. Datesand could accommodate all our requirements and with a very short lead time. The lab device is exactly what we had hoped for, if not better. The quality of the service we received from the Datesand group was outstanding and could not be faulted. We will be using Datesand again for future laboratory devices.’

GV-Solas – Germany’s Congress

zoonlab-1GV-Solas is Germany’s equivalent to our IAT Meeting and takes place annually, in September, in one of the many German cities with links to animal laboratory science. This year’s meeting took place a few days ago in Cologne. Naturally enough, Nicky was there to support our fantastic German distributors Zoonlab.

Nicky describes her flying visit

‘On a stormy Monday I headed over to Cologne to join our distribution partners, Zoonlab, at their national conference GV-Solas.  This is the German equivalent meeting to IAT Congress and is held over 3 days.  After a fairly hairy flight on a very small plane I landed in Dusseldorf and picked up a hire car for the short drive to Cologne. I arrive just in time to head out and meet a few British colleagues for a quick beer before heading back to the hotel to get ready for the next day.

zoonlab-3On Tuesday the exhibition opened bright and early at 8am and I was greeted at the Zoonlab booth by their new MD Theodor Feldman.  The stand was impressive and stood out in the hall of 83 exhibiting companies.  They were showcasing their caging and equipment ranges along with our enrichment which they offer into the German market.  They were most impressed with the new polycarbonate enrichment items and I was also pleased to be able to show them the JWI Award Winner – Mouse Swings.   Samples of Mouse Swings were quickly installed in the cage set-ups and drew lots of attention from Zoonlab sales staff and delegates alike.

Mr Feldman and I attended a couple of papers (to test my German!) about enrichment reducing aggression in group-housed mice and also one about bedding depth and thermoregulation.  In summary, enrichment does indeed reduce aggression and deeper bedding provides a warmer home for mice who then eat less as a result.

Late on Tuesday afternoon I said my goodbyes and headed to Cologne airport for my flight home (which was delayed and my case was lost but that’s another story!).  A really good trip and great to be able to support one of our excellent European Distributors at their national meeting.’

 

AS-ET Graduation – Hats off to the students

grad-2Hot on the heels of returning from GV-Solas, I hopped on a train to London to be a guest at the AS-ET Graduation Ceremony.  For those of you reading who are not familiar with AS-ET, it is Animals in Science Education Trust, a charity set up to support education within animal science.  AS-ET has distributed, or is committed to distribute, nearly £100,000 in grants to support education and welfare activities. The bulk of the grants are in the form of bursaries to enable individuals to attend courses to improve their own knowledgrad-3ge and skills. These courses range from specialist short courses  to long formal courses such as those leading to the IAT further and higher education qualifications.

Datesand are a long-term supporter of AS-ET and I also sit on their fundraising committee.  It was an honour to be invited to see this year’s further and higher education students graduate in the surroundings of UCL’s London School of Pharmacy. In 2017 there were 12 Diploma Level 4, 7 diploma Level 5, 2 Diploma Level 6 and 6 Middlesex University BSc Professional Practice in Laboratory Science graduates. Congratulations to all of the students who worked so hard!

The graduation ceremony was attended by Ken Applebee, CEO and Chair of IAT Council, and was addressed by the Guest of Honour Robin Lovell-Badge FRS FMedSci.  After the presentation of the certificates there was a break in the rain long enough for photos on the lawn followed by a dash back inside for a glass of fizz and a sandwich.

It was soon time for a dash through the torrential rain back to the station for the train journey home.